Ontology highlight
ABSTRACT:
SUBMITTER: Schmal C
PROVIDER: S-EPMC6759184 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Schmal Christoph C Ono Daisuke D Myung Jihwan J Pett J Patrick JP Honma Sato S Honma Ken-Ichi KI Herzel Hanspeter H Tokuda Isao T IT
PLoS computational biology 20190912 9
Circadian rhythms are generated by interlocked transcriptional-translational negative feedback loops (TTFLs), the molecular process implemented within a cell. The contributions, weighting and balancing between the multiple feedback loops remain debated. Dissociated, free-running dynamics in the expression of distinct clock genes has been described in recent experimental studies that applied various perturbations such as slice preparations, light pulses, jet-lag, and culture medium exchange. In t ...[more]