Ontology highlight
ABSTRACT:
SUBMITTER: Quail DF
PROVIDER: S-EPMC6759922 | biostudies-literature | 2017 Aug
REPOSITORIES: biostudies-literature
Quail Daniela F DF Olson Oakley C OC Bhardwaj Priya P Walsh Logan A LA Akkari Leila L Quick Marsha L ML Chen I-Chun IC Wendel Nils N Ben-Chetrit Nir N Walker Jeanne J Holt Peter R PR Dannenberg Andrew J AJ Joyce Johanna A JA
Nature cell biology 20170724 8
Obesity is associated with chronic, low-grade inflammation, which can disrupt homeostasis within tissue microenvironments. Given the correlation between obesity and relative risk of death from cancer, we investigated whether obesity-associated inflammation promotes metastatic progression. We demonstrate that obesity causes lung neutrophilia in otherwise normal mice, which is further exacerbated by the presence of a primary tumour. The increase in lung neutrophils translates to increased breast c ...[more]