Dataset Information

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

ABSTRACT:

Background

The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.

Method

Analyses were conducted using data from the Lothian Birth Cohort 1936 (n?=?892). Weights for the epigenetic BMI score were derived using penalised regression on methylation data from unrelated Generation Scotland participants (n?=?2562). Associations were tested for replication in an independent sample: the Lothian Birth Cohort 1921 (n?=?433).

Results

A higher epigenetic BMI score was associated with higher BMI (R²?=?0.1), greater body weight (R²?=?0.06), greater time taken to walk 6?m, poorer lung function and poorer general physical health (all R²?=?0.02), greater levels of triglycerides (R²?=?0.09), greater %total HbA1c (R²?=?0.06), lower levels of high-density lipoprotein cholesterol (HDL; R²?=?0.08), higher HDL ratio (HDL/total cholesterol; R² = 0.03), lower health-related quality of life, physical inactivity, and greater social deprivation (all R²?=?0.02). The epigenetic BMI score (per SD) was also associated with type 2 diabetes (OR 2.17, 95% CI 1.67, 2.84), cardiovascular disease (OR 1.45, 95% CI 1.24, 1.71) and high blood pressure (OR 1.30, 95% CI 1.13, 1.49; all p?2?=?0.06), body weight (R²?=?0.04), health-related quality of life (R²?=?0.02), HbA1c (R²?=?0.07) and triglycerides (R²?=?0.07; all p?ConclusionsWe observed and replicated associations between an epigenetic score for BMI and variables related to poor physical health and metabolic syndrome. Regression models with both epigenetic and phenotypic BMI scores as predictors accounted for a greater proportion of variance in all outcome variables than either predictor alone, demonstrating independent and additive effects of epigenetic and phenotypic BMI scores.

SUBMITTER: Hamilton OKL

PROVIDER: S-EPMC6760607 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

Hamilton Olivia K L OKL Zhang Qian Q McRae Allan F AF Walker Rosie M RM Morris Stewart W SW Redmond Paul P Campbell Archie A Murray Alison D AD Porteous David J DJ Evans Kathryn L KL McIntosh Andrew M AM Deary Ian J IJ Marioni Riccardo E RE

International journal of obesity (2005) 20190306 9

<h4>Background</h4>The relationship between obesity and adverse health is well established, but little is known about the contribution of DNA methylation to obesity-related health outcomes. This study tests associations between an epigenetic score for body mass index (BMI) and health-related, cognitive, psychosocial and lifestyle outcomes in the Lothian Birth Cohort 1936. This study also tests whether these associations are independent of phenotypic BMI.<h4>Method</h4>Analyses were conducted usi ...[more]

PMID: 30842548

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Dataset Information

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

Background

Method

Results

Publications

An epigenetic score for BMI based on DNA methylation correlates with poor physical health and major disease in the Lothian Birth Cohort.

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