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Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis.


ABSTRACT: In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious complications is debated. The present meta-analysis aimed at determining whether systemic antibiotic prophylaxis prevents infectious complications in pediatric patients with burn injuries. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to August 2019. We included 6 studies, in which event rates of infectious complications were reported in children with burn injuries receiving or not receiving systemic antibiotic prophylaxis. We found that the overall odds ratio (OR) of developing an infection (including local and systemic) was not different between the groups (OR = 1.35; 95% CI, 0.44, 4.18). The chances for systemic infectious complications alone were also not different between antibiotic-treated and non-treated patients (OR = 0.74; 95% CI, 0.38, 1.45). Based on the age, affected total body surface area, and country income level, we did not find any subgroup that benefited from the prophylaxis. Our findings provide quantitative evidence for the inefficacy of systemic antibiotic prophylaxis in preventing infections in pediatric burns. To validate our conclusion, multinational, randomized trials in a diverse population of children with burn injuries are warranted.

SUBMITTER: Csenkey A 

PROVIDER: S-EPMC6760783 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis.

Csenkey Alexandra A   Jozsa Gergo G   Gede Noemi N   Pakai Eszter E   Tinusz Benedek B   Rumbus Zoltan Z   Lukacs Anita A   Gyongyi Zoltan Z   Hamar Peter P   Sepp Robert R   Romanovsky Andrej A AA   Hegyi Peter P   Vajda Peter P   Garami Andras A  

PloS one 20190925 9


In pediatric burns the use of systemic antibiotic prophylaxis is a standard procedure in some burn centers, though its beneficial effect on the infectious complications is debated. The present meta-analysis aimed at determining whether systemic antibiotic prophylaxis prevents infectious complications in pediatric patients with burn injuries. We searched the PubMed, EMBASE, and Cochrane Library databases from inception to August 2019. We included 6 studies, in which event rates of infectious comp  ...[more]

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