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Simple and robust polymer-based sensor for rapid cancer detection using serum.

ABSTRACT: We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing.

SUBMITTER: Le NDB

PROVIDER: S-EPMC6760871 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Simple and robust polymer-based sensor for rapid cancer detection using serum.

Le Ngoc D B NDB Singla Arvind K AK Geng Yingying Y Han Jinsong J Seehafer Kai K Prakash Gyan G Moyano Daniel F DF Downey Charlene M CM Monument Michael J MJ Itani Doha D Bunz Uwe H F UHF Jirik Frank R FR Rotello Vincent M VM

Chemical communications (Cambridge, England) 20190901 76

We report a polymer-based sensor that rapidly detects cancer based on changes in serum protein levels. Using three ratiometric fluorescence outputs, this simple system identifies early stage and metastatic lung cancer with a high level of accuracy exceeding many biomarker-based assays, making it an attractive strategy for point-of-care testing. ...[more]

PMID: 31535684

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