Colloidal stability versus self-assembly of nanoparticles controlled by coiled-coil protein interactions.
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ABSTRACT:
SUBMITTER: Siehr A
PROVIDER: S-EPMC6760969 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Colloidal stability versus self-assembly of nanoparticles controlled by coiled-coil protein interactions.
Siehr Allison A Xu Bin B Siegel Ronald A RA Shen Wei W
Soft matter 20190901 36
Orientational discrimination of biomolecular recognition is exploited here as a molecular engineering tool to regulate nanoparticle self-assembly or stability. Nanoparticles are conjugated with the heterodimerizing coiled-coils, A and B, which associate in parallel orientation. Simply flipping the orientation of one coiled-coil results in either self-assembling or colloidally stable nanoparticles. ...[more]
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