Ontology highlight
ABSTRACT:
SUBMITTER: Fu W
PROVIDER: S-EPMC6761190 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Fu Wenyan W Lei Changhai C Liu Shuowu S Cui Yingshu Y Wang Chuqi C Qian Kewen K Li Tian T Shen Yafeng Y Fan Xiaoyan X Lin Fangxing F Ding Min M Pan Mingzhu M Ye Xuting X Yang Yongji Y Hu Shi S
Nature communications 20190925 1
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid and durable clinical responses but is associated with unique acute toxicities. Moreover, CAR-T cells are vulnerable to immunosuppressive mechanisms. Here, we report that CAR-T cells release extracellular vesicles, mostly in the form of exosomes that carry CAR on their surface. The CAR-cont ...[more]