Ontology highlight
ABSTRACT:
SUBMITTER: Li N
PROVIDER: S-EPMC6761205 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Li Nan N Wang Yifan Y Neri Shinya S Zhen Yuanli Y Fong Lon Wolf R LWR Qiao Yawei Y Li Xu X Chen Zhen Z Stephan Clifford C Deng Weiye W Ye Rui R Jiang Wen W Zhang Shuxing S Yu Yonghao Y Hung Mien-Chie MC Chen Junjie J Lin Steven H SH
Nature communications 20190925 1
The LKB1/AMPK pathway plays a major role in cellular homeostasis and tumor suppression. Down-regulation of LKB1/AMPK occurs in several human cancers and has been implicated in metabolic diseases. However, the precise upstream regulation of LKB1-AMPK pathway is largely unknown. Here, we report that AMPK activation by LKB1 is regulated by tankyrases. Tankyrases interact with and ribosylate LKB1, promoting its K63-linked ubiquitination by an E3 ligase RNF146, which blocks LKB1/STRAD/MO25 complex fo ...[more]