Ontology highlight
ABSTRACT:
SUBMITTER: Benoit SL
PROVIDER: S-EPMC6761267 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Benoit Stéphane L SL Schmalstig Alan A AA Glushka John J Maier Susan E SE Edison Arthur S AS Maier Robert J RJ
Scientific reports 20190925 1
The nickel (Ni)-specific chelator dimethylglyoxime (DMG) has been used for many years to detect, quantitate or decrease Ni levels in various environments. Addition of DMG at millimolar levels has a bacteriostatic effect on some enteric pathogens, including multidrug resistant (MDR) strains of Salmonella Typhimurium and Klebsiella pneumoniae. DMG inhibited activity of two Ni-containing enzymes, Salmonella hydrogenase and Klebsiella urease. Oral delivery of nontoxic levels of DMG to mice previousl ...[more]