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Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance.

ABSTRACT: The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics can be expressed by simple mathematical language. A new disease group was revealed and some useful inferences were obtained through mathematical deduction. They were supported by published studies. SCS-based depiction of homeostasis should be a requisite supplement to medical knowledge systems based on NFS.

SUBMITTER: Lu X

PROVIDER: S-EPMC6761279 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Depiction of Physiological Homeostasis by Self-Coupled System and Its Significance.

Lu Xia X Jin Guantao G Chen Wenjin W Yu Xinguang X Ling Feng F

Frontiers in physiology 20190919

The negative feedback system (NFS) was regarded as the basic unit of regulation of physiological homeostasis for more than 70 years. However, NFS-based depiction possesses some limitations. The self-coupled system (SCS), a non-stop system in which the output of the current moment becomes the input of the next moment, can also be utilized to depict homeostasis. In SCS-based depiction, all of the related regulatory mechanisms of a homeostasis are regarded as an entity. Then, homeostatic dynamics c ...[more]

PMID: 31607948

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