Dataset Information

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.

ABSTRACT: Background Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short- and long-term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical characteristics and to assess short- and long-term mortality. A subanalysis was performed comparing long-term mortality between a subset of TTS patients with or without malignancy and acute coronary syndrome (ACS) patients with or without malignancy. Malignancy was observed in 16.6% of 1604 TTS patients. Patients with malignancy were older and more likely to have physical triggers, but less likely to have emotional triggers compared with those without malignancy. Long-term mortality was higher in patients with malignancy (P<0.001), while short-term outcome was comparable (P=0.17). In a subanalysis, long-term mortality was comparable between TTS patients with malignancies and ACS patients with malignancies (P=0.13). Malignancy emerged as an independent predictor of long-term mortality. Conclusions A substantial number of TTS patients show an association with malignancy. History of malignancy might increase the risk for TTS, and therefore, appropriate screening for malignancy should be considered in these patients. Clinical Trial Registration URL: http://www.clinicaltrial.gov. Unique identifier: NCT01947621.

SUBMITTER: Cammann VL

PROVIDER: S-EPMC6761645 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.

Cammann Victoria L VL Sarcon Annahita A Ding Katharina J KJ Seifert Burkhardt B Kato Ken K Di Vece Davide D Szawan Konrad A KA Gili Sebastiano S Jurisic Stjepan S Bacchi Beatrice B Micek Jozef J Frangieh Antonio H AH Napp L Christian LC Jaguszewski Milosz M Bossone Eduardo E Citro Rodolfo R D'Ascenzo Fabrizio F Franke Jennifer J Noutsias Michel M Knorr Maike M Heiner Susanne S Burgdorf Christof C Koenig Wolfgang W Thiele Holger H Tschöpe Carsten C Rajan Lawrence L Michels Guido G Pfister Roman R Cuneo Alessandro A Jacobshagen Claudius C Karakas Mahir M Banning Adrian A Cuculi Florim F Kobza Richard R Fischer Thomas A TA Vasankari Tuija T Airaksinen K E Juhani KEJ Dworakowski Rafal R Kaiser Christoph C Osswald Stefan S Galiuto Leonarda L Dichtl Wolfgang W Delmas Clément C Lairez Olivier O Horowitz John D JD Kozel Martin M Widimský Petr P Tousek Petr P Winchester David E DE Gilyarova Ekaterina E Shilova Alexandra A Gilyarov Mikhail M El-Battrawy Ibrahim I Akin Ibrahim I Ukena Christian C Bauersachs Johann J Pieske Burkert M BM Hasenfuß Gerd G Rottbauer Wolfgang W Braun-Dullaeus Ruediger C RC Opolski Grzegorz G MacCarthy Philip P Felix Stephan B SB Borggrefe Martin M Di Mario Carlo C Crea Filippo F Katus Hugo A HA Schunkert Heribert H Münzel Thomas T Böhm Michael M Bax Jeroen J JJ Prasad Abhiram A Shinbane Jerold J Lüscher Thomas F TF Ruschitzka Frank F Ghadri Jelena R JR Templin Christian C

Journal of the American Heart Association 20190717 15

Background Clinical characteristics and outcomes of takotsubo syndrome (TTS) patients with malignancy have not been fully elucidated. This study sought to explore differences in clinical characteristics and to investigate short- and long-term outcomes in TTS patients with or without malignancy. Methods and Results TTS patients were enrolled from the International Takotsubo Registry. The TTS cohort was divided into patients with and without malignancy to investigate differences in clinical charac ...[more]

PMID: 31311438

Similar Datasets

Project description:Background Takotsubo syndrome (TS) is a potentially life-threatening acute cardiac syndrome with a clinical presentation similar to myocardial infarction and for which the natural history, management, and outcome remain incompletely understood. Our aim was to assess the relative short-term mortality risk of TS, ST-segment-elevation myocardial infarction (STEMI), and non-STEMI (NSTEMI) and to identify predictors of in-hospital complications and poor prognosis in patients with TS. Methods and Results This is an observational cohort study based on the data from the SCAAR (Swedish Coronary Angiography and Angioplasty Registry). We included all patients (n=117 720) who underwent coronary angiography in Sweden attributed to TS (N=2898 [2.5%]), STEMI (N=48 493 [41.2%]), or NSTEMI (N=66 329 [56.3%]) between January 2009 and February 2018. We compared patients with TS to those with NSTEMI or STEMI. The primary end point was all-cause mortality at 30 days. Secondary outcomes were acute heart failure (Killip Class ≥2) and cardiogenic shock (Killip Class 4) at the time of angiography. Patients with TS were more often women compared with patients with STEMI or NSTEMI. TS was associated with unadjusted and adjusted 30-day mortality risks lower than STEMI (adjusted hazard ratio [adjHR], 0.60; 95% CI, 0.48-0.76; P<0.001), but higher than NSTEMI (adjHR, 2.70; 95% CI, 2.14-3.41; P<0.001). Compared with STEMI, TS was associated with a similar risk of acute heart failure (adjHR, 1.26; 95% CI, 0.91-1.76; P=0.16) but a lower risk of cardiogenic shock (adjHR, 0.55; 95% CI, 0.34-0.89; P=0.02). The relative 30-day mortality risk for TS versus STEMI and NSTEMI was higher for smokers than nonsmokers (adjusted P interaction STEMI=0.01 and P interaction NSTEMI=0.01). Conclusions The 30-day mortality rate in TS was higher than in NSTEMI but lower than STEMI despite a similar risk of acute heart failure in TS and STEMI. Among patients with TS, smoking was an independent predictor of mortality.

Dataset Information

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.

Publications

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets