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Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.

ABSTRACT: Background Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-?4 is a genetic susceptibility risk factor for Alzheimer's disease that also moderates vascular damage. This study investigated whether APOE-?4 carrier status modifies the cross-sectional association between cardiac output and cognition. Methods and Results Vanderbilt Memory & Aging Project participants free of clinical stroke and dementia (n=306, 73±7 years, 42% female) underwent echocardiography to determine cardiac output (L/min), comprehensive neuropsychological assessment, and venous blood draw to determine APOE genotype and ?4 carrier status. Linear regressions related cardiac output to neuropsychological test performance, adjusting for age, sex, education, race/ethnicity, body surface area, cognitive diagnosis, Framingham Stroke Risk Profile, and APOE-?4 status. Main effect models were null (P>0.19). With identical covariates, models were repeated testing a cardiac output×APOE-?4 status interaction and again stratified by ?4 carrier status. Cardiac output×APOE-?4 status related to naming (?=0.91, P=0.0009), category fluency (?=1.2, P=0.01), information processing speed (?=-5.4, P=0.001), visuospatial skill (?=0.85, P=0.003), and executive function performances (?=0.22, P=0.002). Stratified models suggested that lower cardiac output was associated with worse neuropsychological performances among APOE-?4 carriers. Conclusions APOE-?4 carrier status appears to modify the cross-sectional association between cardiac output and neuropsychological performance such that lower cardiac output relates to poorer performances among carriers of the ?4 allele. These findings add to increasing evidence that APOE-?4 carrier status has important implications for associations between vascular and brain health in aging adults.

SUBMITTER: Bown CW

PROVIDER: S-EPMC6761646 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.

Bown Corey W CW Liu Dandan D Osborn Katie E KE Gupta Deepak K DK Mendes Lisa A LA Pechman Kimberly R KR Hohman Timothy J TJ Wang Thomas J TJ Gifford Katherine A KA Jefferson Angela L AL

Journal of the American Heart Association 20190731 15

Background Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-ε4 is a genetic susceptibility risk factor for Alzheimer's disease that also moderates vascular damage. This study investigated whether APOE-ε4 carrier status modifies the cross-sectional association between cardiac output and cognition. Methods and Results Vanderbilt Memory & Aging Project participants free of clini ...[more]

PMID: 31364446

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Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.

Publications

Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.

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