Ontology highlight
ABSTRACT:
SUBMITTER: Merkel CD
PROVIDER: S-EPMC6761764 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Merkel Chelsea D CD Li Yang Y Raza Qanber Q Stolz Donna B DB Kwiatkowski Adam V AV
Molecular biology of the cell 20190904 21
The adherens junction (AJ) couples the actin cytoskeletons of neighboring cells to allow mechanical integration and tissue organization. The physiological demands of intercellular adhesion require that the AJ be responsive to dynamic changes in force while maintaining mechanical load. These demands are tested in the heart, where cardiomyocyte AJs must withstand repeated cycles of actomyosin-mediated contractile force. Here we show that force-responsive cardiomyocyte AJs recruit actin-binding lig ...[more]