Ontology highlight
ABSTRACT:
SUBMITTER: Smith MJ
PROVIDER: S-EPMC6761769 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Smith Michael J MJ Bryant Eric E EE Joseph Fraulin J FJ Rothstein Rodney R
Molecular biology of the cell 20190904 21
During S phase in <i>Saccharomyces cerevisiae</i>, chromosomal loci become mobile in response to DNA double-strand breaks both at the break site (local mobility) and throughout the nucleus (global mobility). Increased nuclear exploration is regulated by the recombination machinery and the DNA damage checkpoint and is likely an important aspect of homology search. While mobility in response to DNA damage has been studied extensively in S phase, the response in interphase has not, and the question ...[more]