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Fatty acid based transient nanostructures for temporal regulation of artificial peroxidase activity.


ABSTRACT: Natural systems access transient high energy self-assembled structures for temporal regulation of different biological functions through dissipative processes. Compartmentalization within self-assembled structures is used by living systems to organize vital biochemical reactions that define cellular metabolism. Herein, we demonstrate a simple fatty acid based system where a redox active base (dimethylaminomethyl ferrocene, Fc-NMe2 ) acts as a countercation to access unique hexagonal compartments resulting in the formation of a self-supporting gel. An oxidizing environment helps in the dissipation of energy by converting Fc-NMe2 to oxidized waste and the gel autonomously undergoes transition to a sol. Hence, the system requires the addition of the fuel Fc-NMe2 to access the temporal gel state. Notably, these transient compartments were able to temporally upregulate and downregulate hemin-catalyzed oxidation reactions mimicking peroxidase, a ubiquitous enzyme in extant biology. An order of magnitude variation in k cat values was observed with time and the chemical reaction persists as long as the gel state was present.

SUBMITTER: Ahmed S 

PROVIDER: S-EPMC6761916 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature

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Fatty acid based transient nanostructures for temporal regulation of artificial peroxidase activity.

Ahmed Sahnawaz S   Chatterjee Ayan A   Das Krishnendu K   Das Dibyendu D  

Chemical science 20190701 32


Natural systems access transient high energy self-assembled structures for temporal regulation of different biological functions through dissipative processes. Compartmentalization within self-assembled structures is used by living systems to organize vital biochemical reactions that define cellular metabolism. Herein, we demonstrate a simple fatty acid based system where a redox active base (dimethylaminomethyl ferrocene, <b>Fc-NMe<sub>2</sub></b> ) acts as a countercation to access unique hexa  ...[more]

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