Ontology highlight
ABSTRACT:
SUBMITTER: Zhang H
PROVIDER: S-EPMC6761943 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Zhang He H Zhan Xiaowei X Brugarolas James J Xie Yang Y
Bioinformatics (Oxford, England) 20191001 19
<h4>Motivation</h4>Detection of somatic copy number alterations (SCNAs) using high-throughput sequencing has become popular because of rapid developments in sequencing technology. Existing methods do not perform well in calling SCNAs for the unstable tumor genomes.<h4>Results</h4>We developed a new method, DEFOR, to detect SCNAs in tumor samples from exome-sequencing data. The evaluation showed that DEFOR has a higher accuracy for SCNA detection from exome sequencing compared with the five exist ...[more]