Monocyte Dysfunction, Activation, and Inflammation After Long-Term Antiretroviral Therapy in an African Cohort.
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ABSTRACT: Background
Monocyte dysfunction may persist during antiretroviral therapy (ART).Methods
Frozen peripheral blood mononuclear cells of 30 human immunodeficiency virus (HIV)-infected ART-treated adults with sustained viral suppression and CD4 counts ≥500 cells/µL were consecutively analyzed for monocyte phenotypes and function.Results
Nonclassical monocytes (CD14+, CD16++), interleukin (IL)-1β production, and expression of CD40 and CD86 were lower among ART-treated HIV-infected adults relative to age-matched HIV-negative adults (P = .01, P = .01, and P = .02, respectively). Intestinal fatty acid-binding protein, IL6, and soluble CD14 were higher among HIV-infected adults relative to HIV-negative adults (P = .0002, P = .04, and P = .0017, respectively).Conclusions
Further investigation is required to understand drivers of persistent monocyte activation and dysfunction.
SUBMITTER: Nabatanzi R
PROVIDER: S-EPMC6761975 | biostudies-literature |
REPOSITORIES: biostudies-literature
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