Ontology highlight
ABSTRACT:
SUBMITTER: Suresh K
PROVIDER: S-EPMC6763233 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Suresh Karthik K Naidoo Jarushka J Zhong Qiong Q Xiong Ye Y Mammen Jennifer J de Flores Marcia Villegas MV Cappelli Laura L Balaji Aanika A Palmer Tsvi T Forde Patrick M PM Anagnostou Valsamo V Ettinger David S DS Marrone Kristen A KA Kelly Ronan J RJ Hann Christine L CL Levy Benjamin B Feliciano Josephine L JL Lin Cheng-Ting CT Feller-Kopman David D Lerner Andrew D AD Lee Hans H Shafiq Majid M Yarmus Lonny L Lipson Evan J EJ Soloski Mark M Brahmer Julie R JR Danoff Sonye K SK D'Alessio Franco F
The Journal of clinical investigation 20190716 10
<h4>Background</h4>Checkpoint inhibitor pneumonitis (CIP) is a highly morbid complication of immune checkpoint immunotherapy (ICI), one which precludes the continuation of ICI. Yet, the mechanistic underpinnings of CIP are unknown.<h4>Methods</h4>To better understand the mechanism of lung injury in CIP, we prospectively collected bronchoalveolar lavage (BAL) samples in ICI-treated patients with (n=12) and without CIP (n=6), prior to initiation of first-line therapy for CIP (high dose corticoster ...[more]