Ontology highlight
ABSTRACT:
SUBMITTER: Labrecque MP
PROVIDER: S-EPMC6763249 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Labrecque Mark P MP Coleman Ilsa M IM Brown Lisha G LG True Lawrence D LD Kollath Lori L Lakely Bryce B Nguyen Holly M HM Yang Yu C YC da Costa Rui M Gil RMG Kaipainen Arja A Coleman Roger R Higano Celestia S CS Yu Evan Y EY Cheng Heather H HH Mostaghel Elahe A EA Montgomery Bruce B Schweizer Michael T MT Hsieh Andrew C AC Lin Daniel W DW Corey Eva E Nelson Peter S PS Morrissey Colm C
The Journal of clinical investigation 20190730 10
Metastatic castration-resistant prostate cancer (mCRPC) is a heterogeneous disease with diverse drivers of disease progression and mechanisms of therapeutic resistance. We conducted deep phenotypic characterization of CRPC metastases and patient-derived xenograft (PDX) lines using whole genome RNA sequencing, gene set enrichment analysis and immunohistochemistry. Our analyses revealed five mCRPC phenotypes based on the expression of well-characterized androgen receptor (AR) or neuroendocrine (NE ...[more]