Ontology highlight
ABSTRACT:
SUBMITTER: Keller MP
PROVIDER: S-EPMC6763251 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Keller Mark P MP Rabaglia Mary E ME Schueler Kathryn L KL Stapleton Donnie S DS Gatti Daniel M DM Vincent Matthew M Mitok Kelly A KA Wang Ziyue Z Ishimura Takanao T Simonett Shane P SP Emfinger Christopher H CH Das Rahul R Beck Tim T Kendziorski Christina C Broman Karl W KW Yandell Brian S BS Churchill Gary A GA Attie Alan D AD
The Journal of clinical investigation 20190725 10
Genetic susceptibility to type 2 diabetes is primarily due to β-cell dysfunction. However, a genetic study to directly interrogate β-cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, and measured insulin secretion in response to a variety of secretagogues. Insulin secretion from DO islets ranged >1,000-fold even though none of the mice were diabetic. The insulin secretory response to each ...[more]