Ontology highlight
ABSTRACT:
SUBMITTER: Redpath GMI
PROVIDER: S-EPMC6763463 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Redpath Gregory M I GMI Ecker Manuela M Kapoor-Kaushik Natasha N Vartoukian Haig H Carnell Michael M Kempe Daryan D Biro Maté M Ariotti Nicholas N Rossy Jérémie J
Nature communications 20190926 1
The targeted endocytic recycling of the T cell receptor (TCR) to the immunological synapse is essential for T cell activation. Despite this, the mechanisms that underlie the sorting of internalised receptors into recycling endosomes remain poorly understood. To build a comprehensive picture of TCR recycling during T cell activation, we developed a suite of new imaging and quantification tools centred on photoactivation of fluorescent proteins. We show that the membrane-organising proteins, floti ...[more]