Surface-kinetics mediated mesoporous multipods for enhanced bacterial adhesion and inhibition.

ABSTRACT: Despite the importance of nanoparticle's multipods topology in multivalent-interactions enhanced nano-bio interactions, the precise manipulation of multipods surface topological structures is still a great challenge. Herein, the surface-kinetics mediated multi-site nucleation strategy is demonstrated for the fabrication of mesoporous multipods with precisely tunable surface topological structures. Tribulus-like tetra-pods Fe₃O₄@SiO₂@RF&PMOs (RF?=?resorcinol-formaldehyde resin, PMO?=?periodic mesoporous organosilica) nanocomposites have successfully been fabricated with a centering core@shell Fe₃O₄@SiO₂@RF nanoparticle, and four surrounding PMO nanocubes as pods. By manipulating the number of nucleation sites through mediating surface kinetics, a series of multipods mesoporous nanocomposites with precisely controllable surface topological structures are formed, including Janus with only one pod, nearly plane distributed dual-pods and tri-pods, three-dimensional tetrahedral structured tetra-pods, etc. The multipods topology endows the mesoporous nanocomposites enhanced bacteria adhesion ability. Particularly, the tribulus-like tetra-pods mesoporous nanoparticles show ~100% bacteria segregation and long-term inhibition over 90% after antibiotic loading.

SUBMITTER: Zhao T 

PROVIDER: S-EPMC6763480 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature