Ontology highlight
ABSTRACT:
SUBMITTER: Topal S
PROVIDER: S-EPMC6763489 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190926 1
Dynamic disruption and reassembly of promoter-proximal nucleosomes is a conserved hallmark of transcriptionally active chromatin. Histone H3-K56 acetylation (H3K56Ac) enhances these turnover events and promotes nucleosome assembly during S phase. Here we sequence nascent transcripts to investigate the impact of H3K56Ac on transcription throughout the yeast cell cycle. We find that H3K56Ac is a genome-wide activator of transcription. While H3K56Ac has a major impact on transcription initiation, i ...[more]