Ontology highlight
ABSTRACT:
SUBMITTER: Dejon-Agobe JC
PROVIDER: S-EPMC6763635 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Dejon-Agobe Jean Claude JC Ateba-Ngoa Ulysse U Lalremruata Albert A Homoet Andreas A Engelhorn Julie J Nouatin Odilon Paterne OP Edoa Jean Ronald JR Fernandes José F JF Esen Meral M Mouwenda Yoanne Darelle YD Betouke Ongwe Eunice M EM Massinga-Loembe Marguerite M Hoffman Stephen L SL Sim B Kim Lee BKL Theisen Michael M Kremsner Peter G PG Adegnika Ayôla A AA Lell Bertrand B Mordmüller Benjamin B
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20190901 8
<h4>Background</h4>GMZ2 is a recombinant malaria vaccine inducing immune responses against Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We used standardized controlled human malaria infection (CHMI) to assess the efficacy of this asexual blood-stage vaccine.<h4>Methods</h4>We vaccinated 50 healthy, adult volunteers with lifelong exposure to Pf 3 times, at 4-week intervals, with 30 or 100 µg GMZ2 formulated in CAF01, a liposome-based adjuvant; 100 µg GMZ2, fo ...[more]