Ontology highlight
ABSTRACT:
SUBMITTER: Tanita K
PROVIDER: S-EPMC6763730 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Tanita Kayo K Fujimura Taku T Sato Yota Y Lyu Chunbing C Kambayashi Yumi Y Ogata Dai D Fukushima Satoshi S Miyashita Azusa A Nakajima Hideki H Nakamura Motoki M Morita Akimichi A Aiba Setsuya S
Frontiers in oncology 20190920
Bexarotene is a third-generation retinoid X receptor-selective retinoid that has been approved for use in the treatment of both early and advanced cutaneous T-cell lymphoma (CTCL). Although bexarotene has been used for decades in the treatment of CTCL, little is known about the mechanisms underlying its anti-tumor effects in CTCL patients. This study therefore focused on the immunomodulatory effects of bexarotene <i>in vivo</i> using an EL4 mouse T-cell lymphoma model, followed by investigation ...[more]