Ontology highlight
ABSTRACT:
SUBMITTER: Laudisi F
PROVIDER: S-EPMC6763778 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Laudisi Federica F Cherubini Fabio F Di Grazia Antonio A Dinallo Vincenzo V Di Fusco Davide D Franzè Eleonora E Ortenzi Angela A Salvatori Illari I Scaricamazza Silvia S Monteleone Ivan I Sakamoto Naoya N Monteleone Giovanni G Stolfi Carmine C
Molecular oncology 20190810 10
Persistent activation of Signal Transducer and Activator of Transcription (STAT)3 occurs in a high percentage of tumors, including colorectal cancer (CRC), thereby contributing to malignant cell proliferation and survival. Although STAT3 is recognized as an attractive therapeutic target in CRC, conventional approaches aimed at inhibiting its functions have met with several limitations. Moreover, the factors that sustain hyper-activation of STAT3 in CRC are not yet fully understood. The identific ...[more]