Ontology highlight
ABSTRACT:
SUBMITTER: Akerud P
PROVIDER: S-EPMC6763865 | biostudies-literature | 2001 Oct
REPOSITORIES: biostudies-literature
Akerud P P Canals J M JM Snyder E Y EY Arenas E E
The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001 20
Neural stem cells (NSCs) have been proposed as tools for treating neurodegeneration because of their capacity to give rise to cell types appropriate to the structure in which they are grafted. In the present work, we explore the ability of NSCs to stably express transgenes and locally deliver soluble molecules with neuroprotective activity, such as glial cell line-derived neurotrophic factor (GDNF). NSCs engineered to release GDNF engrafted well in the host striatum, integrated and gave rise to ...[more]