Dataset Information

Cannabis-based product use in a multiple sclerosis cohort.

ABSTRACT:

Objective

The objective of this study was to characterize the use of cannabis-based products (CBPs) by multiple sclerosis (MS) patients who attend the University of British Columbia Hospital (UBCH) MS clinic.

Methods

All patients attending the UBCH MS clinic from January to March 2018 were invited to participate in an anonymous survey that included: patient demographics (sex, age and employment status), self-reported MS-specific data (subtype, disease duration, previous and current disease modifying therapies, symptomatic medications) and CBP use (formulation, frequency, perceived benefits/side-effects). A second cohort of retrospective patient data (CBP use, sex, age, disease subtype and Expanded Disability Status Scale) was extracted from the UBCH MS clinic electronic medical record (EMR).

Results

Of 600 surveys distributed, 188 were returned with completed CBP usage. CBP use was daily for 19% (n?=?37), weekly for 6% (n?=?11), monthly for 4% (n?=?7), rarely for 21% (n?=?39) and 50% (n?=?94) never used. Of the CBP users (daily, weekly and monthly), CBP use included: oral (n?=?43/55), smoked/vaporized (n?=?42/55), topical (n?=?14/55) and mucosal (n?=?5/55). EMR data was available for 561 MS patients where cannabis use/non-use was documented. CBP users represented 19% (107/561).

Conclusions

CBP use is common based on volunteer reporting, with approximately one out of four patients who attend the UBCH MS clinic using CBPs.

SUBMITTER: Schabas AJ

PROVIDER: S-EPMC6764052 | biostudies-literature | 2019 Jul-Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Cannabis-based product use in a multiple sclerosis cohort.

Schabas A J AJ Vukojevic V V Taylor C C Thu Z Z Badyal A A Chan J K JK Devonshire V V Traboulsee A A Sayao A L AL Carruthers R R

Multiple sclerosis journal - experimental, translational and clinical 20190701 3

<h4>Objective</h4>The objective of this study was to characterize the use of cannabis-based products (CBPs) by multiple sclerosis (MS) patients who attend the University of British Columbia Hospital (UBCH) MS clinic.<h4>Methods</h4>All patients attending the UBCH MS clinic from January to March 2018 were invited to participate in an anonymous survey that included: patient demographics (sex, age and employment status), self-reported MS-specific data (subtype, disease duration, previous and curren ...[more]

PMID: 31598330

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Project description:AimsTo identify prototypical developmental patterns of tobacco product and cannabis use and co-use initiation during adolescence, and determine risk factors for and consequences of these initiation patterns.DesignProspective repeated-measures cohort with eight semi-annual assessments during high school. Multiple-event process survival mixture modeling identified latent initiation classes with distinct patterns of variation in timing of use initiation of tobacco products and cannabis. We then estimated: (1) associations of baseline risk factors with membership in initiation classes and (2) differences between initiation classes in frequency of cannabis and tobacco product use at the final assessment.SettingTen high schools in the Los Angeles, CA, USA metropolitan area, 2013-17.ParticipantsStudents [1031 (45.4%) males; mean (standard deviation) age at baseline = 14.6 (0.39) years] who had never used any tobacco products or cannabis at baseline 9th grade assessment (n = 2272).MeasurementsSelf-report measures of electronic cigarette (e-cigarette), combustible cigarette, hookah, cigar/cigarillos and cannabis use were collected at each assessment.FindingsFour distinct tobacco and cannabis use initiation classes were identified: (1) early and high-risk cannabis and polytobacco initiators (n = 116; 5.1%); (2) early cannabis and polytobacco initiators (n = 172; 7.6%); (3) late cannabis and e-cigarette initiators (n = 431; 19.0%); and (4) abstainers (n = 1553; 68.4%). At baseline, older age for the early and high-risk cannabis and polytobacco initiators [odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.10, 1.35, P < 0.001], peer cannabis use (OR = 1.60, 95% CI = 1.23, 2.08, P < 0.001) and delinquent behavior (OR = 1.30, 95% CI = 1.08, 1.55, P = 0.004) were associated with membership in the three initiation classes (versus abstainers). Membership in the early and high-risk cannabis and polytobacco initiators class (versus three other classes) was significantly associated with increased past 30-day frequency and daily intensity of use at the final assessment (P-values < 0.001).ConclusionsOlder age, peer cannabis use and delinquent behavior appear to be risk factors for the initiation of tobacco/cannabis product use among high school students in the Los Angeles metropolitan region. Early and higher-risk polyproduct use initiation appears to be associated with greater escalation of past 30-day and daily tobacco and cannabis use at the end of the high school.

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Dataset Information

Cannabis-based product use in a multiple sclerosis cohort.

Objective

Methods

Results

Conclusions

Publications

Cannabis-based product use in a multiple sclerosis cohort.

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