Ontology highlight
ABSTRACT:
SUBMITTER: Evangelista GCM
PROVIDER: S-EPMC6764084 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Evangelista Gabriela Coeli Menezes GCM Salvador Pollyanna Amaral PA Soares Sara Malaguti Andrade SMA Barros Luciana Rodrigues Carvalho LRC Xavier Felipe Henrique da Cunha FHDC Abdo Luiza Macedo LM Gualberto Ana Cristina Moura ACM Macedo Gilson Costa GC Clavijo-Salomon Maria Alejandra MA Gameiro Jacy J
Frontiers in oncology 20190920
Breast cancer (BC) remains the leading cause of cancer-related deaths among women, and the chances to develop it are duplicated by obesity. Still, the impact of obesity during BC progression remains less understood. We investigated the role of obesity in tumor progression using the murine model of 4T1 mammary carcinoma in BALB/c female mice, previously high-fat-diet (HFD) fed. HFD induced obesity, metabolic impairment, and high serum and fat leptin levels. After injection of 4T1-cells, HFD-mice ...[more]