SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
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ABSTRACT:
SUBMITTER: Koopmans F
PROVIDER: S-EPMC6764089 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse.
Koopmans Frank F van Nierop Pim P Andres-Alonso Maria M Byrnes Andrea A Cijsouw Tony T Coba Marcelo P MP Cornelisse L Niels LN Farrell Ryan J RJ Goldschmidt Hana L HL Howrigan Daniel P DP Hussain Natasha K NK Imig Cordelia C de Jong Arthur P H APH Jung Hwajin H Kohansalnodehi Mahdokht M Kramarz Barbara B Lipstein Noa N Lovering Ruth C RC MacGillavry Harold H Mariano Vittoria V Mi Huaiyu H Ninov Momchil M Osumi-Sutherland David D Pielot Rainer R Smalla Karl-Heinz KH Tang Haiming H Tashman Katherine K Toonen Ruud F G RFG Verpelli Chiara C Reig-Viader Rita R Watanabe Kyoko K van Weering Jan J Achsel Tilmann T Ashrafi Ghazaleh G Asi Nimra N Brown Tyler C TC De Camilli Pietro P Feuermann Marc M Foulger Rebecca E RE Gaudet Pascale P Joglekar Anoushka A Kanellopoulos Alexandros A Malenka Robert R Nicoll Roger A RA Pulido Camila C de Juan-Sanz Jaime J Sheng Morgan M Südhof Thomas C TC Tilgner Hagen U HU Bagni Claudia C Bayés Àlex À Biederer Thomas T Brose Nils N Chua John Jia En JJE Dieterich Daniela C DC Gundelfinger Eckart D ED Hoogenraad Casper C Huganir Richard L RL Jahn Reinhard R Kaeser Pascal S PS Kim Eunjoon E Kreutz Michael R MR McPherson Peter S PS Neale Ben M BM O'Connor Vincent V Posthuma Danielle D Ryan Timothy A TA Sala Carlo C Feng Guoping G Hyman Steven E SE Thomas Paul D PD Smit August B AB Verhage Matthijs M
Neuron 20190603 2
Synapses are fundamental information-processing units of the brain, and synaptic dysregulation is central to many brain disorders ("synaptopathies"). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking. We established SynGO, an interactive knowledge base that accumulates available research about synapse biology using Gene Ontology (GO) annotations to novel ontology terms: 87 synaptic locations and 179 synaptic processes. SynGO annotations are ...[more]
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