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Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols.

ABSTRACT: The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting ¹H NMR signal gains which subsequently approach 10³ per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.

SUBMITTER: Rayner PJ

PROVIDER: S-EPMC6764278 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols.

Rayner Peter J PJ Tickner Ben J BJ Iali Wissam W Fekete Marianna M Robinson Alastair D AD Duckett Simon B SB

Chemical science 20190701 33

The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optim ...[more]

PMID: 31588319

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