Ontology highlight
ABSTRACT:
SUBMITTER: Yang Y
PROVIDER: S-EPMC6764339 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Yang Yi Y Li Na N Chen Tongshuai T Zhang Chunmei C Liu Lingxin L Qi Yan Y Bu Peili P
Pharmaceutical biology 20191201 1
<b>Context:</b> Sunitinib (SU) is a multi-targeted tyrosine kinase inhibitor anticancer agent whose clinical use is often limited by cardiovascular complications. Trimetazidine (TMZ) is an anti-angina agent that has been demonstrated cardioprotective effects in numerous cardiovascular conditions, but its potential effects in SU-induced cardiotoxicity have not been investigated. <b>Objective:</b> This study investigates the effect of TMZ in sunitinib-induced cardiotoxicity <i>in vivo</i> and <i>i ...[more]