Ontology highlight
ABSTRACT:
SUBMITTER: Li W
PROVIDER: S-EPMC6764722 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Li Wenjun W Chaudhari Kiran K Shetty Ritu R Winters Ali A Gao Xiaofei X Hu Zeping Z Ge Woo-Ping WP Sumien Nathalie N Forster Michael M Liu Ran R Yang Shao-Hua SH
Aging and disease 20191001 5
Metformin is currently the most effective treatment for type-2 diabetes. The beneficial actions of metformin have been found even beyond diabetes management and it has been considered as one of the most promising drugs that could potentially slow down aging. Surprisingly, the effect of metformin on brain function and metabolism has been less explored given that brain almost exclusively uses glucose as substrate for energy metabolism. We determined the effect of metformin on locomotor and cogniti ...[more]