Ontology highlight
ABSTRACT:
SUBMITTER: Xu J
PROVIDER: S-EPMC6764819 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Xu Jiajia J Wang Yiyun Y Hsu Ching-Yun CY Gao Yongxing Y Meyers Carolyn Ann CA Chang Leslie L Zhang Leititia L Broderick Kristen K Ding Catherine C Peault Bruno B Witwer Kenneth K James Aaron Watkins AW
eLife 20190904
The vascular wall is a source of progenitor cells that are able to induce skeletal repair, primarily by paracrine mechanisms. Here, the paracrine role of extracellular vesicles (EVs) in bone healing was investigated. First, purified human perivascular stem cells (PSCs) were observed to induce mitogenic, pro-migratory, and pro-osteogenic effects on osteoprogenitor cells while in non-contact co-culture via elaboration of EVs. PSC-derived EVs shared mitogenic, pro-migratory, and pro-osteogenic prop ...[more]