Ontology highlight
ABSTRACT:
SUBMITTER: Adams JN
PROVIDER: S-EPMC6764824 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Adams Jenna N JN Maass Anne A Harrison Theresa M TM Baker Suzanne L SL Jagust William J WJ
eLife 20190902
Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer's disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than ...[more]