Distinct single-cell signaling characteristics are conferred by the MyD88 and TRIF pathways during TLR4 activation.

ABSTRACT: Toll-like receptors (TLRs) recognize specific pathogen-associated molecular patterns and initiate innate immune responses through signaling pathways that depend on the adaptor proteins MyD88 (myeloid differentiation marker 88) or TRIF (TIR domain-containing adaptor protein-inducing interferon-β). TLR4, in particular, uses both adaptor proteins to activate the transcription factor nuclear factor κB (NF-κB); however, the specificity and redundancy of these two pathways remain to be elucidated. We developed a mathematical model to show how each pathway encodes distinct dynamical features of NF-κB activity and makes distinct contributions to the high variability observed in single-cell measurements. The assembly of a macromolecular signaling platform around MyD88 associated with receptors at t

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC6764925 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature