MicroRNA arm-imbalance in part from complementary targets mediated decay promotes gastric cancer progression.

ABSTRACT: Strand-selection is the final step of microRNA biogenesis in which functional mature miRNAs are generated from one or both arms of precursor. The preference of strand-selection is diverse during development and tissue formation, however, its pathological effect is still unknown. Here we find that two miRNA arms from the same precursor, miR-574-5p and miR-574-3p, are inversely expressed and play exactly opposite roles in gastric cancer progression. Higher-5p with lower-3p expression pattern is significantly correlated with higher TNM stages and poor prognosis of gastric cancer patients. The increase of miR-574-5p/-3p ratio, named miR-574 arm-imbalance is partially due to the dynamic expression of their highly complementary targets in gastric carcinogenesis, moreover, the arm-imbalance of mi

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC6764945 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature