Ontology highlight
ABSTRACT:
SUBMITTER: Ayala-Nunez NV
PROVIDER: S-EPMC6764950 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nature communications 20190927 1
Zika virus (ZIKV) invades and persists in the central nervous system (CNS), causing severe neurological diseases. However the virus journey, from the bloodstream to tissues through a mature endothelium, remains unclear. Here, we show that ZIKV-infected monocytes represent suitable carriers for viral dissemination to the CNS using human primary monocytes, cerebral organoids derived from embryonic stem cells, organotypic mouse cerebellar slices, a xenotypic human-zebrafish model, and human fetus b ...[more]