Ontology highlight
ABSTRACT:
SUBMITTER: Pensar J
PROVIDER: S-EPMC6765119 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Pensar Johan J Puranen Santeri S Arnold Brian B MacAlasdair Neil N Kuronen Juri J Tonkin-Hill Gerry G Pesonen Maiju M Xu Yingying Y Sipola Aleksi A Sánchez-Busó Leonor L Lees John A JA Chewapreecha Claire C Bentley Stephen D SD Harris Simon R SR Parkhill Julian J Croucher Nicholas J NJ Corander Jukka J
Nucleic acids research 20191001 18
Covariance-based discovery of polymorphisms under co-selective pressure or epistasis has received considerable recent attention in population genomics. Both statistical modeling of the population level covariation of alleles across the chromosome and model-free testing of dependencies between pairs of polymorphisms have been shown to successfully uncover patterns of selection in bacterial populations. Here we introduce a model-free method, SpydrPick, whose computational efficiency enables analys ...[more]