Ontology highlight
ABSTRACT:
SUBMITTER: Begley V
PROVIDER: S-EPMC6765136 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Begley Victoria V Corzo Daniel D Jordán-Pla Antonio A Cuevas-Bermúdez Abel A Miguel-Jiménez Lola de L Pérez-Aguado David D Machuca-Ostos Mercedes M Navarro Francisco F Chávez María José MJ Pérez-Ortín José E JE Chávez Sebastián S
Nucleic acids research 20191001 18
Co-transcriptional imprinting of mRNA by Rpb4 and Rpb7 subunits of RNA polymerase II (RNAPII) and by the Ccr4-Not complex conditions its post-transcriptional fate. In turn, mRNA degradation factors like Xrn1 are able to influence RNAPII-dependent transcription, making a feedback loop that contributes to mRNA homeostasis. In this work, we have used repressible yeast GAL genes to perform accurate measurements of transcription and mRNA degradation in a set of mutants. This genetic analysis uncovere ...[more]