Ontology highlight
ABSTRACT:
SUBMITTER: Grunewald S
PROVIDER: S-EPMC6766871 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Grünewald Sylvia S Politz Oliver O Bender Sebastian S Héroult Mélanie M Lustig Klemens K Thuss Uwe U Kneip Christoph C Kopitz Charlotte C Zopf Dieter D Collin Marie-Pierre MP Boemer Ulf U Ince Stuart S Ellinghaus Peter P Mumberg Dominik D Hess-Stumpp Holger H Ziegelbauer Karl K
International journal of cancer 20190313 5
Aberrant activation in fibroblast growth factor signaling has been implicated in the development of various cancers, including squamous cell lung cancer, squamous cell head and neck carcinoma, colorectal and bladder cancer. Thus, fibroblast growth factor receptors (FGFRs) present promising targets for novel cancer therapeutics. Here, we evaluated the activity of a novel pan-FGFR inhibitor, rogaratinib, in biochemical, cellular and in vivo efficacy studies in a variety of preclinical cancer model ...[more]