Ontology highlight
ABSTRACT:
SUBMITTER: Hsieh CY
PROVIDER: S-EPMC6767017 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190906 18
Numerous reports have shown that conjugated benzimidazole derivatives possess various kinds of biological activities, including anticancer properties. In this report, we designed and synthesized 24 new molecules comprising a benzimidazole ring, arene, and alkyl chain-bearing cyclic moieties. The results showed that the <i>N</i>-substituted benzimidazole derivatives bearing an alkyl chain and a nitrogen-containing 5- or 6-membered ring enhanced the cytotoxic effects on human breast adenocarcinoma ...[more]