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Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii.


ABSTRACT: Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of Torreya fargesii (T. fargesii) by fractionation. Fractionated kernel oil of T. fargesii (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 ?g/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 ?g/mL) more effectively than the non-fractionated oil. This shows that increasing the amount of sciadonic acid can enhance the anti-inflammatory effect of the kernel oil. This research also indicates that fractionation is a feasible way to obtain sciadonic acid-rich functional oil with potential pharmacological effects.

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6767029 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Fractionated Antioxidant and Anti-inflammatory Kernel Oil from <i>Torreya fargesii</i>.

Zhou Xianrong X   Shang Jin J   Qin Mingyi M   Wang Jianhua J   Jiang Bo B   Yang Hui H   Zhang Yan Y  

Molecules (Basel, Switzerland) 20190919 18


Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of <i>Torreya fargesii</i> (<i>T. fargesii</i>) by fractionation. Fractionated kernel oil of <i>T. fargesii</i> (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil.  ...[more]

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