Dataset Information

Carbon Nanoparticles Inhibit ?-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice.

ABSTRACT: New, improved therapies to reduce blood glucose are required for treating diabetes mellitus (DM). Here, we investigated the use of a new nanomaterial candidate for DM treatment, carbon nanoparticles (CNPs). CNPs were prepared by carbonization using a polysaccharide from Arctium lappa L. root as the carbon source. The chemical structure and morphology of the CNPs were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, elemental analysis, and transmission electron microscopy. CNPs were spherical, 10-20 nm in size, consisting of C, H, O, and N, and featuring various functional groups, including C=O, C=C, C-O, and C-N. In vitro, the as-prepared CNPs could inhibit ?-glucosidase with an IC50 value of 0.5677 mg/mL, which is close to that of the reference drug acarbose. Moreover, in vivo hypoglycemic assays revealed that the CNPs significantly reduced fasting blood-glucose levels in mice with diabetes induced by high-fat diet and streptozocin, lowering blood glucose after intragastric administration for 42 days. To the best of our knowledge, this is the first report of CNPs exhibiting ?-glucosidase inhibition and a hypoglycemic effect in diabetic mice. These findings suggest the therapeutic potential of CNPs for diabetes.

SUBMITTER: Shao T

PROVIDER: S-EPMC6767295 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Carbon Nanoparticles Inhibit Α-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice.

Shao Taili T Yuan Pingchuan P Zhu Lei L Xu Honggang H Li Xichen X He Shuguang S Li Ping P Wang Guodong G Chen Kaoshan K

Molecules (Basel, Switzerland) 20190906 18

New, improved therapies to reduce blood glucose are required for treating diabetes mellitus (DM). Here, we investigated the use of a new nanomaterial candidate for DM treatment, carbon nanoparticles (CNPs). CNPs were prepared by carbonization using a polysaccharide from <i>Arctium lappa</i> L. root as the carbon source. The chemical structure and morphology of the CNPs were characterized using Fourier-transform infrared spectroscopy, X-ray photoelectron spectroscopy, elemental analysis, and tran ...[more]

PMID: 31500170

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Dataset Information

Carbon Nanoparticles Inhibit ?-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice.

Publications

Carbon Nanoparticles Inhibit Α-Glucosidase Activity and Induce a Hypoglycemic Effect in Diabetic Mice.

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