Ontology highlight
ABSTRACT:
SUBMITTER: Chia YL
PROVIDER: S-EPMC6767326 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Clinical pharmacology and therapeutics 20190322 2
We evaluated the relationship between benralizumab (30 mg every 4 and 8 weeks (Q4W, Q8W)) pharmacokinetic (PK) exposure and end points of asthma exacerbation rates (AERs) and change from baseline in prebronchodilator forced expiratory volume in 1 second (FEV<sub>1</sub> ) for patients with severe, uncontrolled eosinophilic asthma in the SIROCCO/CALIMA phase III trials. In empirical assessment, AER ratios in SIROCCO were similar across PK quartiles. However, the lowest PK quartile in CALIMA had r ...[more]