Dataset Information

Saccade latencies during a preferential looking task and objective scoring of grating acuity in children with and without visual impairments.

ABSTRACT:

Purpose

We determined the latencies of orienting responses during a preferential looking task in children with normal vision and in children with visual impairments between 6 and 12 years old, and assessed the feasibility of scoring grating detection in these populations with video-based eye tracking.

Methods

Children performed a computerized preferential looking test, while a remote eye tracker measured the children's eye movements. The stimuli consisted of a 2 × 2 grid, with three uniform grey fields and one target field consisting of a black-and-white square wave grating. The grating was presented randomly at one of the four locations. The spatial frequencies (1.05, 2.11 and 7.02 cyc/deg) were randomly interleaved, with 10 trials per spatial frequency. Three different methods were used to score the accuracy of the responses: (1) primary saccade ends on target, (1) gaze 50% of the presentation time on target, and (3) a combination of method 1 and 2 (i.e. primary saccade ends on target, and/or gaze 50% of the presentation time on target).

Results

The combined scoring method was most reliable to determine whether children could resolve the gratings. Children with visual impairments had significantly lower accuracies than children with normal vision with all three scoring methods. In addition, saccade latencies decreased with age and were significantly longer (62 ± 15 ms) in children with visual impairments.

Conclusion

The use of eye tracking to assess grating detection with a preferential looking task in clinical populations provides valuable additional information, including objective detection measures and developmental delays in saccade latencies.

SUBMITTER: Barsingerhorn AD

PROVIDER: S-EPMC6767583 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature

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Publications

Saccade latencies during a preferential looking task and objective scoring of grating acuity in children with and without visual impairments.

Barsingerhorn Annemiek D AD Boonstra F Nienke FN Goossens Jeroen J

Acta ophthalmologica 20190207 6

<h4>Purpose</h4>We determined the latencies of orienting responses during a preferential looking task in children with normal vision and in children with visual impairments between 6 and 12 years old, and assessed the feasibility of scoring grating detection in these populations with video-based eye tracking.<h4>Methods</h4>Children performed a computerized preferential looking test, while a remote eye tracker measured the children's eye movements. The stimuli consisted of a 2 × 2 grid, with thr ...[more]

PMID: 30734501

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Project description:To evaluate the reliability and validity of grating visual acuity (VA) and contrast sensitivity (CS) tests, which could be useful outcome measures to assess changes in severely reduced vision.The Grating Acuity Test (GAT) and Grating Contrast Sensitivity (GCS) tests, which involve the detection of grating orientation in a four-Alternative Forced Choice paradigm on a liquid crystal display screen, were compared with the well-validated Early Treatment of Diabetic Retinopathy Study (ETDRS) and Pelli-Robson (PR) charts. Grating tests were repeated two or three times within-visit, across three or four sessions, in 20 legally blind subjects: 8 with retinitis pigmentosa (RP) (16 eyes) and 12 with other retinal diseases (OR) (16 eyes).VA determined by ETDRS and GAT was in good agreement and scaled very similarly, as shown by regression of the within-session difference between the two measures against their mean [RP group: slope (m) = 0.11; 95% confidence interval [CI]: -0.06, 0.29; p = 0.21; OR group: m = -0.07; 95% CI: 0.33, 0.20; p = 0.62]. On average, higher logCS levels were obtained using the GCS than the PR in both groups. The two CS measures scaled similarly in the RP group (m = 0.07; 95% CI: -0.09, 0.22; p = 0.39) but not in the OR group (m = 0.41; 95% CI: 0.12, 0.70; p = 0.005). The within- and between-visit 95% coefficient of repeatability (CR.95) were 0.11 to 0.17 log units for the ETDRS charts and GAT in both groups and 0.14 to 0.15 log units for the PR and GCS in the RP group, whereas the OR group demonstrated more variability in CS. Between-visit CR.95 did not significantly change with mean VA or CS for the ETDRS, PR, or GCS tests, but RP patients' CR.95 on the GAT increased significantly with decreasing VA. Floor effects occurred for some RP eyes with ETDRS and PR charts but not with the GAT and GCS.Computer-driven grating tests appear to be reliable, capable of evaluating vision that may fall outside of the range of standard clinical tests and may be useful during clinical trials for advanced eye disease.

Dataset Information

Saccade latencies during a preferential looking task and objective scoring of grating acuity in children with and without visual impairments.

Purpose

Methods

Results

Conclusion

Publications

Saccade latencies during a preferential looking task and objective scoring of grating acuity in children with and without visual impairments.

Similar Datasets

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