Ontology highlight
ABSTRACT:
SUBMITTER: Houghton PJ
PROVIDER: S-EPMC6768308 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Houghton Peter J PJ Kurmasheva Raushan T RT
Pharmacological reviews 20191001 4
Cancer in children is rare with approximately 15,700 new cases diagnosed in the United States annually. Through use of multimodality therapy (surgery, radiation therapy, and aggressive chemotherapy), 70% of patients will be "cured" of their disease, and 5-year event-free survival exceeds 80%. However, for patients surviving their malignancy, therapy-related long-term adverse effects are severe, with an estimated 50% having chronic life-threatening toxicities related to therapy in their fourth or ...[more]