Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children.

ABSTRACT:

Background

Chronic cadmium exposure has been associated with osteotoxicity in adults, but little is known concerning its effects on early growth, which has been shown to be impaired by cadmium.

Objectives

Our objective was to assess the impact of early-life cadmium exposure on bone-related biomarkers and anthropometry at 9 y of age.

Methods

For 504 children in a mother-child cohort in Bangladesh, cadmium exposure was assessed by concentrations in urine (U-Cd, long-term exposure) and erythrocytes (Ery-Cd, ongoing exposure) at 9 and 4.5 y of age, and in their mothers during pregnancy. Biomarkers of bone remodeling [urinary deoxypyridinoline (DPD), urinary calcium, plasma parathyroid hormone, osteocalcin, vitamin D3, insulin-like growth factor (IGF) 1, IGF binding protei

SUBMITTER: Malin Igra A 

PROVIDER: S-EPMC6768315 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature