Network Topologies That Can Achieve Dual Function of Adaptation and Noise Attenuation.
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ABSTRACT:
SUBMITTER: Qiao L
PROVIDER: S-EPMC6768439 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
Network Topologies That Can Achieve Dual Function of Adaptation and Noise Attenuation.
Qiao Lingxia L Zhao Wei W Tang Chao C Nie Qing Q Zhang Lei L
Cell systems 20190918 3
Many signaling systems execute adaptation under circumstances that require noise attenuation. Here, we identify an intrinsic trade-off existing between sensitivity and noise attenuation in the three-node networks. We demonstrate that although fine-tuning timescales in three-node adaptive networks can partially mediate this trade-off in this context, it prolongs adaptation time and imposes unrealistic parameter constraints. By contrast, four-node networks can effectively decouple adaptation and n ...[more]
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