Ontology highlight
ABSTRACT:
SUBMITTER: Zhao DY
PROVIDER: S-EPMC6768649 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Zhao Dorothy Yanling DY Pöge Matthias M Morizumi Takefumi T Gulati Sahil S Van Eps Ned N Zhang Jianye J Miszta Przemyslaw P Filipek Slawomir S Mahamid Julia J Plitzko Jürgen M JM Baumeister Wolfgang W Ernst Oliver P OP Palczewski Krzysztof K
The Journal of biological chemistry 20190809 39
Imaging of rod photoreceptor outer-segment disc membranes by atomic force microscopy and cryo-electron tomography has revealed that the visual pigment rhodopsin, a prototypical class A G protein-coupled receptor (GPCR), can organize as rows of dimers. GPCR dimerization and oligomerization offer possibilities for allosteric regulation of GPCR activity, but the detailed structures and mechanism remain elusive. In this investigation, we made use of the high rhodopsin density in the native disc memb ...[more]